Adjuvant adriamycin and cis-diamminedichloroplatinum (cis-platinum) in primary osteosarcoma
نویسندگان
چکیده
منابع مشابه
Intra-arterial cis-platinum in osteosarcoma.
Conventional radiography continues to be the most important imaging modality in the initial diagnosis and assessment of skeletal neoplasms. However, this technique is usually inadequate to determine the local extent of the tumor, particularly in malignancies. Angiography also fails to define accurately the local extent of most skeletal neoplasms. Computed tomography, however, demonstrates the i...
متن کاملRenal complications of cis-diamminedichloroplatinum.
The use of cis-diamminedichloroplatinum II (DDP), an active agent against special cancer types, is limited by its nephrotoxicity. It damages the proximal tubular epithelium and may cause specific tubular dysfunctions, such as elevation of enzymes and 2 beta microglobulin in the urine or, under special conditions, low calcium and/or magnesium serum concentrations. Cis-diamminedichloroplatinum II...
متن کاملEffect of step-down heating on the cytotoxicity of adriamycin, bleomycin, and cis-diamminedichloroplatinum.
The cytotoxicity of a number of anticancer drugs can be potentiated by mild hyperthermia. Since the cytotoxicity of low-hyperthermic temperatures in the range of 39-43 degrees can be potentiated by using a step-down heating (SDH) sequence (short times at greater than or equal to 45 degrees followed by longer times at lower temperatures), we investigated the combined effects of SDH (specifically...
متن کاملSynthesis of Cis-Diammine (1,1-cyclobutane dicarboxylate) Platinum(II)
Platinum-based anticancer drugs are chemotherapeutic agents to treat cancer. Carboplatin (cis diammine cyclobutane dicarboxylate platinum (II)) is a second generation drug that has less toxic than cisplatin, allowing for high dosages. In the first stage, 1,3-Cyclobutane dicarboxylic acid, a key intermediate for the preparation of carboplatin, have been synthesized in good yields using diffe...
متن کاملDistribution and Disposition of Platinum following Intravenous Administration of cis-Diamminedichloroplatinum(ll) (NSC 119875) to Dogs
cis-Diamminedichloroplatinum(ll) is an antineoplastic drug that is undergoing a renewed clinical interest as a drug for use in combination regimens. In order to increase the understanding of the pharmacokinetics of this drug, the plasma clearance and organ distribution of platinum were followed in female beagle dogs treated with a single i.v. dose of cis-diamminedichloroplatinum(ll). Plasma lev...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer
سال: 1981
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19810115)47:2<248::aid-cncr2820470208>3.0.co;2-e